A surrogate-primary replacement algorithm for response-adaptive randomization in stroke clinical trials

Can response-adaptive randomization increase participation in acute stroke trials?

BACKGROUND AND PURPOSE A response-adaptive randomization (RAR) trial design actively adjusts the ratio of participants assigned to each trial arm, favoring the better performing treatment by using outcome data from participants already in the trial. Compared with a standard clinical trial, an RAR study design has the potential to improve patient participation in acute stroke trials. METHODS T...

Practical Bayesian Adaptive Randomization in Clinical Trials

While randomization is the established method for obtaining scientifically valid treatment comparisons in clinical trials, it sometimes is at odds with what physicians feel is good medical practice. If a physician favors one treatment over another based on personal experience or published data, it may be more appropriate ethically for that physician to use the favored treatment, rather than enr...

Some Caveats for Outcome Adaptive Randomization in Clinical Trials

A Bayesian Response-Adaptive Randomization Design for Clinical Trials with Survival Endpoints

Accordingly to FDA draft guidance (2010), adaptive randomization (e.g. responseadaptive (RA) randomization) has become popular in clinical research because of its flexibility and efficiency, which also have the advantage of assigning fewer patients to inferior treatment arms. The RA design based on binary outcome is commonly used in clinical trial where “success” is defined as the desired (or u...

A Bayesian Response-Adaptive Randomization Design for Clinical Trials with Survival Endpoints

Accordingly to FDA draft guidance (2010), adaptive randomization (e.g. responseadaptive (RA) randomization) has become popular in clinical research because of its flexibility and efficiency, which also have the advantage of assigning fewer patients to inferior treatment arms. The RA design based on binary outcome is commonly used in clinical trial where “success” is defined as the desired (or u...